Research progress on the mechanism of CRMP2 phosphorylation in Alzheimer's disease

VernacularTitle:CRMP2磷酸化参与阿尔茨海默病的机制研究进展
Author: Xuan LIANG ¹ ; Jingran MU ; Yan LUO ; Tao XU ; Junwei ZENG
Author Information

1. 遵义医科大学生理学教研室(贵州遵义 563000)
Keywords: CRMP2; Alzheimer disease; microtubule; mitochondrial
From: The Journal of Practical Medicine 2024;40(10):1467-1472
CountryChina
Language:Chinese
Abstract: Alzheimer's disease(AD)is a common neurological degenerative disease.Collapsin response mediator protein2(CRMP2)plays an important role in the progression of AD.Hyperphosphorylation of CRMP2 results in decreased stability of axonal terminal microtubules and abnormal axoplasmic transport of neurons,which leads to abnormal mitochondrial dynamics of neurons,inhibits the ability of lysosomal autophagy,and leads to excessive activation of NMDA receptors.The phosphorylation of CRMP2 provides a new idea for AD drug develop-ment.In this review,the molecular mechanisms of CRMP2 involved in AD are reviewed,which can provide refer-ences for the development of targeted drugs.