The progress and challenges in immunotherapy for the difficulty- to- treat liver diseases
10.3760/cma.j.cn501113-20210714-00341
- VernacularTitle:难治性肝病免疫治疗的进展与挑战
- Author:
Jin FAN
1
;
Xiuying MU
;
Xiaoyan GUO
;
Yuntian GUO
;
Cheng ZHEN
;
Yanning SONG
;
Fusheng WANG
Author Information
1. 解放军总医院第五医学中心感染病医学部，北京 100039
- Keywords:
Immune;
Therapeutic;
Liver disease
- From:
Chinese Journal of Hepatology
2021;29(7):609-614
- CountryChina
- Language:Chinese
-
Abstract:
As a digestive organ, the liver has the functions of metabolism, synthesis, and detoxification. It is also an immune organ and plays an important role in maintaining anti-infection, autoimmune stability, and anti-tumor. In particular, the liver has unique immunological advantages. Its immune cells can maintain the liver's immune homeostasis and participate in immunoregulation. A variety of immunotherapy is used in clinical trials for the treatment of difficult and critical liver diseases. This review mainly summarizes the recent clinical trials of immunotherapy in chronic hepatitis B, cirrhosis, hepatocellular carcinoma, and autoimmune liver disease.
