Analysis of factors influencing radiation-induced liver injury caused by stereotactic radiotherapy in patients with primary hepatocellular carcinoma
10.3760/cma.j.cn501113-20200221-00058
- VernacularTitle:原发性肝细胞癌患者立体定向放射治疗所致的放射性肝损伤影响因素分析
- Author:
Dan ZHANG
1
;
Jing SUN
;
Jia WANG
;
Dong LI
;
Junqiang DING
;
Huijun XU
;
Wengang LI
;
Xuezhang DUAN
Author Information
1. 解放军总医院第五医学中心（原解放军第三○二医院）肿瘤放射治疗科，北京 100039
- Keywords:
Hepatocellular carcinoma;
White blood cell;
Stereotactic body radiotherapy;
Radiation-induced liver disease
- From:
Chinese Journal of Hepatology
2021;29(6):575-579
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the factors influencing radiation-induced liver injury after receiving Cyberknife stereotactic radiotherapy in patients with primary hepatocellular carcinoma.Methods:278 cases with primary hepatocellular carcinoma from July 2016 to April 2019 were prospectively enrolled. Stereotactic radiosurgery with a prescription dose of 48-55gy/5-8 times were given. Liver function, coagulation function, Child-Pugh score, and liver imaging changes were dynamically observed before and after treatment to evaluate the occurrence of radiation-induced liver injury. Logistic regression model was used to analyze the factors influencing radiation-induced liver injury.Results:Among 278 cases, 3 cases of tumor progression were excluded, and a total of 275 cases were included for analysis. The overall survival rate after 8 months of treatment was 100%. Among them, 22 cases were diagnosed as radiation-induced liver injury, with an incidence rate of 8%, and all cases were recovered after symptomatic treatment. Multivariate analysis result suggested that the peripheral white blood cell count was factors influencing the occurrence of radiation-induced liver injury.Conclusion:Cyberknife stereotactic radiotherapy has a low incidence of radiation-induced liver injury in patients with liver cancer, and it is a relatively safe treatment method. Patients with low peripheral white blood cell counts before treatment should be closely monitored for early detection and treatment.
