Research advances on the regulation of microglia polarization by autophagy in ischemic stroke
10.3969/j.issn.1006-5725.2024.09.025
- VernacularTitle:自噬调控小胶质细胞极化在缺血性脑卒中的研究进展
- Author:
Fangming WANG
1
;
Wenxuan SHANG
;
Jingwen ZHANG
;
Yingxiao JI
;
Litao LI
Author Information
1. 河北医科大学研究生院(石家庄 050017)
- Keywords:
ischemic stroke;
autophagy;
microglia
- From:
The Journal of Practical Medicine
2024;40(9):1324-1330
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke is feature by high incidence,high disability and high mortality.Inflammation plays an important role in the occurrence and development of ischemic stroke.Activated microglia exhibit two different phenotypes of proinflammatory(M1)and anti-inflammatory(M2),and regulating the transformation of microglia from M1 to M2 is the key to clinical benefit.Recent studies have shown that autophagy plays a key role in regulating phenotypic transformation of microglia.How to exert the regulatory role of autophagy and promote the transformation of microglia into M2 type has become a hotspot of clinical research in reducing secondary brain injury after stroke.This paper reviews the research progress of autophagy regulation of microglia polarization in ischemic stroke,aim-ing to provide a reference for further clinical and basic research in this field.
