Research progress in the effects of microRNAs on cardiac electrophysiological properties

VernacularTitle:microRNAs对心脏电生理特性影响的研究进展
Author: Jing YI ¹ ; Hong GAO ; Sisi PAN
Author Information

1. 贵州医科大学附属医院麻醉科(贵阳 550004)
Keywords: microRNA; cardiac electrophysiology; arrhythmia
From: The Journal of Practical Medicine 2024;40(9):1320-1323
CountryChina
Language:Chinese
Abstract: The incidence of perioperative arrhythmias is 4%～20%in noncardiac surgery and 10%～30%in cardiothoracic surgery,with the incidence of perioperative arrhythmias in cardiac surgery patients as high as 90%.Perioperative arrhythmias can prolong hospitalization and increase morbidity and mortality during hospitalization.Studies have shown that aberrantly expressed microRNAs in cardiovascular diseases can participate in cardiac auto-maticity,excitability and conductivity by regulating ion channels,gap junction proteins,and intracellular Ca2+ handling proteins,thereby regulating cardiac electrophysiological homeostasis and arrhythmias.In this article,we will review the research progress of microRNAs and arrhythmias mainly from the perspective of cardiac electrophysi-ological imbalance.