Expression and clinical significance of interleukin-16 in patients with primary biliary cholangitis
10.3760/cma.j.cn501113-20210329-00145
- VernacularTitle:白细胞介素-16在原发性胆汁性胆管炎患者肝组织和血清中的表达及其临床意义
- Author:
Qiaoyan LIU
1
;
You LI
;
Xiong MA
;
Ruqi TANG
Author Information
1. 上海交通大学医学院附属仁济医院消化内科 上海市消化疾病研究所 200001
- Keywords:
Interleukin-16;
Cholestasis;
Primary biliary cholangitis;
Adaptive immunity;
Chemotactic cytokines
- From:
Chinese Journal of Hepatology
2021;29(6):527-532
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expressional condition of interleukin-16 (IL-16) in the liver and serum of patients with primary biliary cholangitis (PBC).Methods:Liver biopsies samples were collected from 70 cases and 10 healthy controls, and serum samples were collected from 62 cases and 87 healthy controls. The expression of IL-16 in liver was detected by immunohistochemistry, and the serum level of IL-16 was determined by enzyme-linked immunosorbent assay. The correlation between the expression level of IL-16 and the severity of disease was determined by correlation analysis with clinical biomarker. The t-test was used for normally distributed data. Wilcoxon signed rank sum test was used for non-normally distributed data.Results:The expression level of IL-16 in the liver of PBC patients was significantly higher than that in the healthy control group ( P = 0.002 5), and it was mainly expressed in infiltrating lymphocytes in the portal area. Correlation analysis showed that the level of IL-16 in liver tissue was positively correlated with the degree of liver inflammation ( r = 0.36, P = 0.002). In addition, the serum IL-16 level of PBC patients were significantly higher than that of healthy people ( P = 0.000 5), and serum IL-16 level was correlated with the level of cholestasis biomarker γ-glutamyltransferase ( r = 0.31, P = 0.03). Conclusion:The expression level of IL-16 is significantly increased in liver and serum of PBC patients, and it is positively correlated with the severity of the disease, suggesting that IL-16 may be used as a biomarker to assess the severity of the disease.
