Immune cells role and their new potential therapeutic targets in the pathogenesis of alcoholic liver disease
10.3760/cma.j.cn501113-20210505-00221
- VernacularTitle:免疫细胞在酒精性肝病发病机制中的作用及潜在治疗新靶点
- Author:
Feiyu ZHANG
1
;
Yanhang GAO
Author Information
1. 吉林大学第一医院肝胆胰内科，长春 130021
- Keywords:
Liver diseases, alcoholic;
Immune cells;
Therapeutic target
- From:
Chinese Journal of Hepatology
2021;29(6):510-514
- CountryChina
- Language:Chinese
-
Abstract:
The key factors driving the pathogenesis of alcoholic liver disease are still not fully understood. At present, it is believed that the direct toxic effects of ethanol and its intermediate metabolite acetaldehyde can cause oxidative stress, mitochondrial damage, adipogenesis, malnutrition, intestinal endotoxin leakage, etc., thereby participating in the occurrence and progression of alcoholic liver disease. Among the many pathogenic factors that have been revealed, the immunological mechanism plays an important role. Therefore, the role of immune cells and inflammatory mediators has attracted much attention. This article reviews and summarizes the new progress of specific immune cell mechanisms involved in innate and adaptive immune response during the formation and development of alcoholic liver disease, and proposes potential therapeutic targets and clinical trials of related new drugs, which may improve the re-recognition of molecular mechanism and treatment expectation in clinical practice.
