The joint efficacy of NBP and LIPost C in treatment of elderly patients with large atherosclerotic cerebral infarction
10.3969/j.issn.1006-5725.2024.09.018
- VernacularTitle:老年大动脉粥样硬化型脑梗死患者采用NBP与LIPost C联合治疗的效果分析
- Author:
Song LI
1
;
Xingyou HE
;
Dian HE
;
Bo WANG
;
Yu ZHAN
;
Jingjing SUN
Author Information
1. 浙江省人民医院毕节医院神经内科(贵州毕节 551700)
- Keywords:
butylphthalide injection;
limb ischemic postconditioning;
large artery atherosclerotic cerebral infarction;
neurological function;
cognitive function
- From:
The Journal of Practical Medicine
2024;40(9):1286-1292
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the joint efficacy of butylphthalide(NBP)and limb ischemic postcondi-tioning(LIPost C)in the treatment of elderly patients with atherosclerotic cerebral infarction.Methods A total of 160 patients with large atherosclerotic cerebral infarction hospitalized in Bijie Hospital from October 2020 to October 2022 were divided into four groups:NBP,LIPost C,NBP + sham LIPost C,and NBP + LIPost C by the random number table method,with 40 cases in each group.Before and after one-month treatment,the four groups were compared in terms of collateral circulation evaluated by the leptomeningeal scoring(rLMC),neurological function evaluated by the National Institutes of Health Stroke Scale(NIHSS),limb function disability evaluated by the Modified Rankin Scale(MRS),cognitive function evaluated by the Mini Mental State Scale(MMSE),daily living ability evaluated by the Barthel Index,as well as the occurrence of bleeding adverse events.Results After one-month treatment,the four groups all showed an increase in the rLMC score,with the NBP + LIPost C group significantly higher than the other three groups(P＜0.05),and a decrease in the scores of NIHSS and MRS at each time point,with the NBP + LIPost C group significantly lower than the other three groups(P＜0.05).Additionally,the four groups demonstrated an increase in the MMSE score and Barthel index at each time point(P＜0.05),with the NBP + LIPost C group higher than the other three groups(P＜0.05).Moreover,all the four groups showed no statistically significant difference in the incidence of bleeding adverse events(P＞0.05).Conclusion NBP com-bined with LIPost C can effectively promote the establishment of collateral circulation and the recovery of neurological function in elderly patients with atherosclerotic cerebral infarction.Meanwhile,it can improve their motor function,daily living ability,and cognitive function.Moreover,it has high safety.
