Immune pathogenesis of primary biliary cholangitis
10.3760/cma.j.cn501113-20210430-00213
- VernacularTitle:原发性胆汁性胆管炎免疫发病机制
- Author:
Mingyue ZHANG
1
;
Jun ZHAO
;
Huan XIE
;
Qingsheng LIANG
;
Zhengsheng ZOU
;
Ying SUN
Author Information
1. 解放军总医院第五医学中心肝病医学部，北京 100039
- Keywords:
Primary biliary cholangitis;
Intrahepatic biliary epithelial cells;
Immunopathogenesis
- From:
Chinese Journal of Hepatology
2021;29(6):500-504
- CountryChina
- Language:Chinese
-
Abstract:
Primary biliary cholangitis (PBC) is an autoimmune liver disease, mainly characterized by chronic progressive cholestasis. The root cause of PBC is the loss of immune tolerance to autoantigen E2 subunit of pyruvate dehydrogenase (PDC-E2). The unique immunobiological characteristics of intrahepatic bile duct epithelial cells make it an active participant in the pathogenesis of PBC. In recent years, the detection rate of PBC has been increasing year by year, but the clinical situation of ursodeoxycholic acid monotherapy has not changed. Therefore, an in-depth understanding of the immune pathogenesis of PBC will help clinicians better prevent and treat diseases.
