Research progress of neural precursor cells-expressed developmentally down-regulated protein-8 in liver diseases
10.3760/cma.j.cn501113-20190918-00341
- VernacularTitle:神经前体细胞表达发育下调蛋白-8在肝脏疾病中的研究进展
- Author:
Jie SUN
1
;
Deyuan ZHANG
;
Jing WANG
;
Yinying LU
Author Information
1. 解放军总医院第五医学中心肝脏肿瘤诊疗与研究中心，北京 100039
- Keywords:
Liver diseases;
Hepatocellular carcinoma;
Neural precursor cell-expressed developmentally downregulated 8;
Neddylation
- From:
Chinese Journal of Hepatology
2021;29(2):188-192
- CountryChina
- Language:Chinese
-
Abstract:
Neural precursor cells-expressed developmentally down-regulated protein-8 (NEDD8) is one of the important members of the ubiquitin family, which plays an important role in maintaining cell stability, cell cycle regulation, signal transduction, transcription, and translation, DNA repair, and tumorigenesis through covalently bound substrates (also known as neddylation modification). In recent years, studies have found that the dysfunction of NEDD8 and its related enzymes is common in liver diseases, and is widely involved in the biological processes of hepatitis, liver fibrosis, proliferation, invasion, apoptosis and autophagy of liver cancer cells. This article focuses on the research progress of NEDD8 in liver diseases.
