Mixed konjac glucomannan regulates immunity of the cyclophosphamide-induced immunosuppressed mice

VernacularTitle:混改魔芋多糖对环磷酰胺诱导的免疫低下小鼠的免疫调节
Author: Jiajia DAI ^{1
,

2} ; Yuyan ZHOU ; Jing OU ; Yuhan YANG ; Chuanhu XI ; Guodong WANG
Author Information

1. 皖南医学院公共卫生学院,安徽芜湖 241002
2. 安徽省多糖药物工程技术研究中心
Keywords: mixed konjac glucomannan; cyclophosphamide; immunomodulation; immunosuppression
From: Journal of Shenyang Medical College 2024;26(5):474-479
CountryChina
Language:Chinese
Abstract: Objective:To investigate the immunomodulatory effect of mixed konjac glucomannan(MKGM)on cyclophosphamide-induced immunosuppressed mice.Methods:The immunosuppressed mice model was established by cyclophosphamide.After treatment with MKGM for 25 d,organ index,lymphocyte proliferation,macrophage function,NK cell killing,and cytokine secretion of mice were observed.Results:Immunomodulatory effect of MKGM was firstly enhanced and then declined.Compared to model group,there were significant differences in organ index,lymphocyte proliferation,macrophage function,NK cell killing,and hemolysin in the medium-dose MKGM group(P＜0.01).HE staining showed that the low-dose MKGM had the best effect on repairing spleen injury caused by cyclophosphamide.However,medium-and high-dose MKGM had relatively weak immunomodulatory effects.Conclusion:The appropriate dose of MKGM can play an immunomodulatory role in the cyclophosphamide-induced immunosuppressed mice.