Research progress on molecular mechanism and treatment for anaplastic thyroid carcinoma
10.16753/j.cnki.1008-2344.2024.03.016
- VernacularTitle:甲状腺未分化癌分子机制和治疗的研究进展
- Author:
You LI
1
;
Hongpeng GUO
;
Yitong ZHANG
;
Junliang LIU
;
Jianhua YU
;
Jinhui ZHANG
;
Chenglin SUN
Author Information
1. 沈阳医学院附属中心医院普外科,辽宁 沈阳 110024
- Keywords:
anaplastic thyroid cancer;
gene mutation;
targeted therapy
- From:
Journal of Shenyang Medical College
2024;26(3):309-315
- CountryChina
- Language:Chinese
-
Abstract:
Anaplastic thyroid carcinoma(ATC)is the most aggressive malignancy with poor prognosis.The pathogenesis of ATC is complex,and there is no effective treatment at present.In recent years,with the deep understanding of the genetic(such as BRAF V600E,TP53,TERT,PIK3CA mutations,etc.)and epigenetic(such as histone methylation,histone deacetylation,microRNA regulatory pathways,etc.)changes driving ATC,molecular targeted therapy has brought new hope to ATC patients.This article reviews the molecular mechanisms of ATC and the latest achievements in targeted therapy and other therapies.
