Tumor Size as a Prognostic Factor in Gastric Cancer Patient.
10.5230/jgc.2012.12.3.164
- Author:
Won Jin IM
1
;
Min Gyu KIM
;
Tae Kyung HA
;
Sung Joon KWON
Author Information
1. Department of Surgery, Hanyang University College of Medicine, Seoul, Korea. sjkwon@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Gastric cancer;
Tumor size;
Prognosis
- MeSH:
Gastrectomy;
Humans;
Multivariate Analysis;
Prognosis;
Serous Membrane;
Stomach Neoplasms;
Survival Rate
- From:Journal of Gastric Cancer
2012;12(3):164-172
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The purpose of this study is to investigate the prognostic significance of tumor size for 5-year survival rate in patients with gastric cancer. MATERIALS AND METHODS: A total of 1,697 patients with gastric cancer, who underwent potentially curative gastrectomy, were evaluated. Patients were divided into 4 groups as follows, according to the median size of early and advanced gastric cancer, respectively: small early gastric cancer (tumor size < or =3 cm), large early gastric cancer (tumor size >3 cm), small advanced gastric cancer (tumor size < or =6 cm), and large advanced gastric cancer (tumor size >6 cm). The prognostic value of tumor size for 5-year survival rate was investigated. RESULTS: In a univariate analysis, tumor size is a significant prognostic factor in advanced gastric cancer, but not in early gastric cancer. Multivariate analysis showed that tumor size is an independent prognostic factor for 5-year survival rate in advanced gastric cancer (P=0.003, hazard ratio=1.372, 95% confidence interval=1.115~1.690). When advanced gastric cancer is subdivided into 2 groups, according to serosa invasion: Group 1; serosa negative (T2 and T3, 7th AJCC), and Group 2; serosa positive (T4a and T4b, 7th AJCC), tumor size is an independent prognostic factor in Group 1 (P=0.011, hazard ratio=1.810, 95% confidence interval=1.149~2.852) and in Group 2 (P=0.033, hazard ratio=1.288, 95% confidence interval=1.020~1.627), respectively. CONCLUSIONS: Tumor size is an independent prognostic factor in advanced gastric cancer irrespective of the serosa invasion, but not in early gastric cancer.
