Clinical analysis of 2 820 cases of drug-induced liver injury
10.3760/cma.j.cn501113-20200609-00305
- VernacularTitle:2 820例药物性肝损伤临床分析
- Author:
Fangjiao SONG
1
;
Qinghui ZHAI
;
Qingjuan HE
;
Sa LYU
;
Bing ZHU
;
Tianjiao XU
;
Hua TIAN
;
Shaojie XIN
;
Shaoli YOU
Author Information
1. 解放军总医院第五医学中心肝衰竭诊疗与研究中心，北京 100039
- Keywords:
Drug induced liver injury;
Clinical features;
Retrospective study
- From:
Chinese Journal of Hepatology
2020;28(11):954-958
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical characteristics, incidence trend, underlying diseases, causative drug and prognosis of drug-induced liver injury (DILI), so as to provide basis for its prevention and treatment.Methods:A retrospective study was conducted on 2 820 DILI cases who were admitted to our hospital from January 2002 to December 2015, and their clinical characteristics, incidence trends, underlying related diseases, causative drug, treatment and outcome were analyzed.Results:Among 2 820 DILI cases, the ratio of male to female was 1:1.44, and the age was (44.00±16.32) years old. According to the clinical classification of DILI, there were 2 353 cases (83.43%) of hepatocyte injury, 353 cases (12.51%) of cholestatic type and 114 cases (4.04%) of mixed type. In the three clinical classification of DILI, there was no statistically significant difference in the ratio of male to female (χ 2 = 3.032, P > 0.05). However, the difference in the ratio of male to female between different age groups was statistically significant (χ 2 = 48.367, P < 0.001). Among the patients with liver disease and acute liver disease admitted to our hospital from January 2002 to December 2015, the proportion of DILI and acute DILI showed an overall upward trend. The main underlying related diseases of 2 820 DILI cases were fever (15.14%), skin diseases (11.84%), cardiovascular and cerebrovascular diseases (11.17%). Chinese herbal patent medicines (37.49%), antibiotics (15.85%), antipyretic-analgesics (14.37%), and so on were the main causative drugs involved, and the prognostic differences among the three clinical classifications of DILI in terms of cure, improvement, ineffectiveness, and death were statistically significant ( H = 61.300, P < 0.001). Conclusion:In recent years, among the patients with liver disease in our hospital, the proportion of DILI has shown an obvious upward trend, involving a variety of underlying diseases and causative drugs, and thus it needs clinical attention.
