Research progress of hepatocyte transplantation treatment for alpha-1 antitrypsin deficiency
10.3760/cma.j.cn501113-20201103-00593
- VernacularTitle:肝细胞移植治疗α-1抗胰蛋白酶缺乏症的研究进展
- Author:
Weijie XU
1
;
Jingfang XIAO
;
Yemiao CHEN
;
Jianqiang DING
Author Information
1. 陆军军医大学（第三军医大学）西南医院感染科，重庆 400038
- Keywords:
α-1 antitrypsin deficiency;
Hepatocyte;
Stem cell;
Cell transplantation
- From:
Chinese Journal of Hepatology
2020;28(11):973-976
- CountryChina
- Language:Chinese
-
Abstract:
Alpha-1 antitrypsin deficiency is an autosomal codominant genetic disease characterized by low levels of alpha-1 antitrypsin in the blood. Clinically, in young patients, it mainly manifests as emphysema, acute/chronic liver injury and liver cancer. The treatment methods include symptomatic treatment and alpha -1 antitrypsin supplementation. However, the existing treatment cannot prevent the liver fibrosis progression. At present, more than ten cases of the disease have been reported in China, but the understanding of this disease is still indecisive. Moreover, there exists no biotherapy drug for this disorder. This article introduces the research progress of hepatocyte transplantation treatment for this disorder.
