Diagnostic value of non-invasive model for hepatic steatosis in patients infected with human immunodeficiency virus
10.3760/cma.j.cn501113-20200820-00469
- VernacularTitle:无创模型对人类免疫缺陷病毒感染者肝细胞脂肪变性的诊断价值
- Author:
Defa ZHANG
1
;
Shuang LI
;
Yuqiang MI
;
Ping MA
Author Information
1. 天津市第二人民医院 天津市肝病研究所 300192
- Keywords:
Fats;
Diagnosis;
HIV
- From:
Chinese Journal of Hepatology
2020;28(9):790-793
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Hepatic steatosis has a high incidence in human immunodeficiency virus (HIV) infected people, and there is no effective non-invasive method to evaluate it. This study aims to evaluate the diagnostic value of non-invasive models for hepatic steatosis in this population.Methods:A single-center retrospective study was applied to evaluate: (1) the diagnostic value of controlled attenuation parameters (CAP) and hepatic steatosis index (HSI) in HIV-infected patients with hepatic steatosis; (2) the ability of the non-invasive model to distinguish hepatic steatosis caused by abnormal glucose and lipid metabolism and hepatic steatosis caused by hepatitis C virus infection; (3) the diagnostic value of the above models for hepatic steatosis in patients co-infected with HIV/hepatitis C virus. The diagnostic value of the model was analyzed and evaluated by diagnostic test and receiver operating characteristic curve.Results:(1) the diagnostic value of hepatic steatosis for HIV-infected patients: when CAP = 232 dB/m, the sensitivity and specificity were 89.2% and 78.1%, respectively; when HSI = 34, the sensitivity and specificity were 79.1% and 83.2%, respectively. (2) The ability to identify the causes of hepatic steatosis in HIV-infected patients: when CAP = 258dB/m, the sensitivity and specificity were 81.5% and 88.2%, respectively; when HSI = 37, the sensitivity and specificity were 70.7% and 92.4%, respectively. (3) The diagnostic value of hepatic steatosis in patients co-infected with HIV/hepatitis C virus: when CAP = 241 dB/m, the sensitivity and specificity were 80% and 71.4%, respectively; when HSI = 32, the sensitivity and specificity were 73% and 68.9%, respectively.Conclusion:CAP and HSI have superior diagnostic value for hepatic steatosis in patients infected with HIV.
