A new strategy for non-invasive diagnosis of liver diseases: DSA-FACE technology based-glycomics method
10.3760/cma.j.cn501113-20190122-00028
- VernacularTitle:肝病无创诊断新策略：DSA-FACE技术的糖组学方法
- Author:
Guanting LU
1
;
Cuiying CHEN
;
Beiling LI
;
Jinjun CHEN
Author Information
1. 南方医科大学南方医院肝病中心，广州 510515
- Keywords:
Liver disease;
Non-invasive diagnosis;
Glycosylation;
Fluorescence capillary electrophoresis
- From:
Chinese Journal of Hepatology
2020;28(9):803-808
- CountryChina
- Language:Chinese
-
Abstract:
Chronic liver disease has gradually become a serious health problem worldwide. Liver biopsy is the current gold standard to assess liver lesions; however, it is an invasive procedure that may cause severe complications. Therefore, there is an urgent need for an economical and rapid non-invasive detection method that can be used in clinic for diagnosis. In the past decade, protein glycosylation has become a research hotspot, and the concept of changes in serum proteoglycans structure has gradually been accepted by many researchers as an indication of liver injury. At the same time, N-linked glycans via DNA sequencing equipment-Fluorophore Assisted Carbohydrate Electrophoresis (DSA-FACE) has also brought high sensitivity and specificity diagnostic models (GlycoHepatoTest) for various chronic liver diseases, which is a new strategy for non-invasive diagnosis of liver diseases.
