Effect of pyroptosis in the pathogenesis of alcoholic liver disease
10.3760/cma.j.cn501113-20191223-00477
- VernacularTitle:焦亡在酒精性肝病发病机制中的作用
- Author:
Yuting DENG
1
;
Feng WEI
;
Junying ZHOU
Author Information
1. 河北医科大学第三医院感染科，石家庄 050051
- Keywords:
Endotoxemia;
Inflammation;
Factors;
Alcoholic liver disease;
Pyroptosis
- From:
Chinese Journal of Hepatology
2020;28(8):715-718
- CountryChina
- Language:Chinese
-
Abstract:
Long-term intake of large amounts of ethanol leads to enterogenous endotoxemia. Reactive oxygen species, high concentrations of adenosine triphosphate and uric acid activate the pyroptosis system, which then cleaves the pore formation mechanism of gasdermin-D, leading to the death of liver cells, accompanied by the release of interleukin-1β, interleukin-18, and other inflammatory factors. This series of processes activates the immune system, mediates a cascade of inflammation, and promotes the development of alcoholic liver disease from steatosis to inflammation and fibrosis.
