Expression and clinical significance of ANO1 in oral squamous cell carcinoma
10.3969/j.issn.1001-3733.2024.04.009
- VernacularTitle:口腔鳞状细胞癌中ANO1的表达及临床意义
- Author:
Hongjuan YAN
1
;
Xiaoping MA
;
Man LI
;
Nan WU
;
Xiaoxue TANG
;
Min CHEN
;
Jiang XU
Author Information
1. 832000,石河子大学第一附属医院口腔科
- Keywords:
Oral squamous cell carcinoma;
A NO 1;
Immunohistochemistry;
qRT-PCR;
Prognosis
- From:
Journal of Practical Stomatology
2024;40(4):508-512
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression and prognostic value of ANO1 in oral squamous cell carcinoma(OSCC)tissues.Methods:Immunohistochemistry(IHC,n=163)and Quantitative real-time PCR(qRT-PCR,n=42)were employed to detect the expression level of ANO1 protein and mRNA in OSCC tissues and paracancerous normal tissues.The relationship between ANO1 ex-pression and clinicopathological features(n=163)and prognosis(n=93)of the patients were analyzed,and the results were compared with those in TCGA database.Results:IHC and qRT-PCR confirmed that ANO1 was highly expressed in OSCC(P＜0.05),which was consistent with the results of the TCGA database.Cox regression analysis showed that ANO1 expression was significantly correlated with T stage,lymph node metastasis and TNM stage and poor prognosis(P＜0.05).By Cox regression analysis,ANO1 overexpression(P=0.002)and differentiation degree(P=0.034)were independent prognostic factors.Conclusion:ANO1 is highly expressed in OSCC and is correlated with poor prognosis,which can be used as a novel biomarker for poor prognosis of OSCC patients.
