Diagnostic value of liver stiffness measurement for the evaluation of liver fibrosis in nonalcoholic fatty liver
10.3760/cma.j.cn501113-20190302-00065
- VernacularTitle:肝脏弹性测定对非酒精性脂肪性肝纤维化诊断价值的评估
- Author:
Jing NING
1
;
Mingjie YAO
;
Shuhong LIU
;
Guangde ZHOU
;
Yun ZHANG
;
Mingyu LI
;
Leijie WANG
;
Lu WANG
;
Jingmin ZHAO
;
Fengmin LU
Author Information
1. 北京大学基础医学院病原生物学系暨感染病研究中心 100191
- Keywords:
Liver fibrosis;
Fatty liver, nonalcoholic;
Liver stiffness measurement (LSM)
- From:
Chinese Journal of Hepatology
2020;28(7):567-572
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical and diagnostic value of liver stiffness measurement (LSM) for the evaluation and comparison of aspartate aminotransferas/platelet ratio index (APRI), fibrosis 4 indexes (FIB-4) and NAFLD fibrosis score (NFS) with liver fibrosis staging in relation to nonalcoholic fatty liver disease (NAFLD).Methods:103 cases with NAFLD who met the inclusion criteria confirmed by liver biopsy were selected for retrospective analysis. The results of serological tests and LSM were recorded. The APRI, FIB-4 and NFS were calculated. The accuracy and applicability of four liver fibrosis models in the diagnosis of liver fibrosis in NAFLD patients were compared with the receiver operating characteristic curve (ROC), and the diagnostic cut-off value of LSM was established.Results:Varying degrees of LSM, APRI, FIB-4 and NFS had shown positive correlations with the increasing degree of liver fibrosis. Among them, LSM was positively correlated with the degree of liver fibrosis, and the correlation coefficient was r = 0.727, P < 0.0001. Consistent with this, the area under the receiver operating characteristic curve, sensitivity, and specificity of LSM diagnosis of liver fibrosis in different stages was significantly higher than APRI, FIB-4 and NFS. Area under receiver operating characteristic curve of LSM was 0.862 and 0.928 for significant liver fibrosis ( f ≥ 2), and advanced liver fibrosis ( f ≥ 3). Conclusion:LSM has a good diagnostic exclusion value for NAFLD-induced fibrosis, and its sensitivity and specificity are better than APRI, FIB-4 and NFS.
