Construction of HA coating on PEEK surface based on magnetron sputtering and its biosafety evaluation
10.3969/j.issn.1001-3733.2024.04.003
- VernacularTitle:基于磁控溅射的PEEK表面HA涂层构建及其生物安全性评估
- Author:
Tianyuan MA
1
;
Bin LU
;
Fuwei LIU
;
He XIN
;
Yicheng CHEN
;
Xuelian JIA
;
Simin ZHU
;
Junrui ZHANG
;
Xiaona NING
Author Information
1. 710032 西安,口颌系统重建与再生全国重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔疾病临床医学研究中心,空军军医大学第三附属医院口腔颌面外科
- Keywords:
Polyether ether ketone;
Hydroxyapatite coating;
Magnetron sputtering;
Biosafety
- From:
Journal of Practical Stomatology
2024;40(4):467-472
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare hydroxyapatite(HA)coating on polyether ether ketone(PEEK)surface by magnetron sputtering technique and to study its biosafety.Methods:Sulfonated PEEK was used to increase the binding area and HA coating was constructed on it using magnetron sputtering technology.SEM and energy dispersive spectroscopy(EDAX)were used to detect the construction effect.Cell adhesion assay,cytoskeletal fluorescence staining and SEM validation were used to assess cytologrcal safety.In vivo safety tests were conducted in SD rats and golden hamsters.Results:HA coating with gradient morphology was successfully constructed on the PEEK surface using above technique.The coating promoted cell adhesion,extension and proliferation.No systemic toxicity and no sig-nificant influence in HE staining of the main infernal organs samples were observed.The coating alleviated the oral mucosal irritation caused by simple sulfonation to a certain extent.Conclusion:HA coating can be prepared stably with magnetron sputtering technology and can meet the biosafety needs for clinical applications.
