Aldehyde dehydrogenase with hepatocellular carcinoma
10.3760/cma.j.cn501113-20200311-00198
- VernacularTitle:乙醛脱氢酶与肝癌
- Author:
Wenjun WANG
1
;
Yanhang GAO
Author Information
1. 吉林大学第一医院肝胆胰内科，长春 130021
- Keywords:
Hepatocellular carcinoma;
Polymorphism, single nucleotide;
Aldehyde dehydrogenase
- From:
Chinese Journal of Hepatology
2020;28(6):475-478
- CountryChina
- Language:Chinese
-
Abstract:
Acetaldehyde dehydrogenase 2 (ALDH2) is a key enzyme in liver acetaldehyde metabolism (product of ethanol metabolism). Globally, about 8% of the population and about 30% to 40% of the East Asian population carry defective genes that encode no / low activity ALDH2. Recently, many studies have focused on the relationship between ALDH and viral hepatitis, alcoholic liver disease, liver fibrosis and liver cancer. Importantly, ALDH2 expression is closely related to the risk, pathogenesis and prognosis of liver cancer, so it can be used as a potential therapeutic target. This article summarizes and reviews the new progress and new research directions of this field.
