Pancreatoduodenectomy and non-alcoholic fatty liver disease
10.3760/cma.j.cn501113-20200426-00214
- VernacularTitle:胰十二指肠切除术与非酒精性脂肪性肝病
- Author:
Shitian YANG
1
;
Chuan SHEN
;
Wei WANG
;
Yadong WANG
;
Caiyan ZHAO
Author Information
1. 河北医科大学第三医院感染科，石家庄 050051
- Keywords:
Fatty liver, non-alcoholic;
Pancreaticoduodenectomy;
Pathogenesis
- From:
Chinese Journal of Hepatology
2020;28(6):540-544
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease (NAFLD) is a clinicopathological syndrome with similar hepatic histological changes to alcoholic liver disease, but without a history of excessive alcohol intake. Obesity, hyperlipidemia, diabetes, hypertension and other metabolic disorders are closely related to its occurrence and development, and its core mechanism is insulin resistance. In addition, there are also non-metabolic-related factors for the occurrence of non-alcoholic fatty liver disease, such as pancreatoduodenectomy. Pancreatoduodenectomy is the standard procedure for the treatment of tumor around the head of pancreas and ampulla. Postoperative pancreatic malfunction induced by pancreatic exocrine function after pancreatoduodenectomy is associated with the occurrence and development of secondary non-alcoholic fatty liver disease.
