Progress in antiviral treatment of hepatitis C after liver transplantation
10.3760/cma.j.cn501113-20190902-00320
- VernacularTitle:肝移植术后丙型肝炎抗病毒治疗进展
- Author:
Jingyue WANG
1
;
Lai WEI
;
Yuan HUANG
;
Jiahong DONG
Author Information
1. 清华大学附属北京清华长庚医院肝胆内科 清华大学临床医学院，北京 102218
- Keywords:
Hepatitis C virus;
Liver transplantation;
Antiviral therapy;
Direct-acting antivirals agents
- From:
Chinese Journal of Hepatology
2020;28(5):452-456
- CountryChina
- Language:Chinese
-
Abstract:
Recipients who detect hepatitis C virus (HCV) ribonucleic acid during the liver transplantation will promptly infect the transplanted liver, so it is called recurrent HCV after liver transplantation. HCV recurrence can lead to the progression of fibrosis and cirrhosis to the transplanted liver, and thereby significantly reduce the transplanted liver survival rate. Therefore, the effective elimination of HCV is the key to improve the patients’ prognosis. Patients should receive antiviral therapy as long as HCV RNA can be detected after liver transplantation, and treatment should be stopped as soon as the disease condition stabilizes. Currently, highly safe pan-genotypic direct-acting antiviral drugs (DAA) have been recommended to patients after liver transplantation, as their interaction with immunosuppressive drugs (DDI) is minimal. Clinically, different treatment scheme should be selected according to the hepatorenal function, and DDIs of the patient. This article reviews the current situation and progress of antiviral treatment for HCV infection after liver transplantation.
