Bile acids in arrhythmia
10.3760/cma.j.cn501113-20190308-00074-1
- VernacularTitle:胆汁酸与心律失常
- Author:
Jingjing YAN
1
;
Huiqian FAN
;
Ling YANG
Author Information
1. 华中科技大学同济医学院附属协和医院消化内科 ，武汉 430000
- Keywords:
Bile acid;
Arrhythmia;
Muscarinic M2 receptors;
Ursodeoxycholic acid
- From:
Chinese Journal of Hepatology
2020;28(4):361-364
- CountryChina
- Language:Chinese
-
Abstract:
With the research advances on bile acid, it has gradually been discovered and confirmed that high levels of bile acids can cause various types of arrhythmias, such as sinus bradycardia, atrial fibrillation (AF), atrioventricular block and even occurrence of cardiac arrest in severe cases. In addition, it has also been found that fetuses are more susceptible to bile acid-induced arrhythmias than adults. It has been recognized that bile acids can cause arrhythmias through a variety of mechanisms, such as the effect of bile acids on ions and ion channels, receptor-mediated, vagal-mediated, and other pathways. Ursodeoxycholic acid (UDCA) is currently found to have protective effect on the heart and has an antiarrhythmic effect. This article mainly reviews the function and mechanism of bile acid in arrhythmia.
