Research progress of liver sinusoidal endothelial cells in the regulation of liver microenvironment to affect liver fibrosis
10.3760/cma.j.cn501113-20190715-00247
- VernacularTitle:肝窦内皮细胞调控肝脏微环境影响肝纤维化的研究进展
- Author:
Xiuxiu DENG
1
;
Hui LI
;
Zefeng ZHANG
;
Qunli GU
Author Information
1. 成都中医药大学附属医院中心实验室 610072；成都中医药大学临床学院 610072
- Keywords:
Liver sinusoidal endothelial cells;
Hepatic microenvironment;
Liver fibrosis
- From:
Chinese Journal of Hepatology
2020;28(4):357-360
- CountryChina
- Language:Chinese
-
Abstract:
Liver sinusoidal endothelial cells (LSECs) are not only important intermediary cells for substance exchange between blood and hepatocytes, but also important hepatic non-parenchymal cells to cause liver fibrosis and cirrhosis because of chronic liver injury factors. It mainly regulates the liver microcirculation and participates in the development of hepatic fibrosis by interacting with hepatic stellate cells (HSCs), hepatocytes, Kupffer cells and mediating hepatic stiffness and hepatic angiogenesis. Hence, clarifying these mechanisms will help to explore new targets and strategies for the treatment of liver fibrosis.
