Circadian clock and non-alcoholic fatty liver disease
10.3760/cma.j.cn501113-20200304-00084
- VernacularTitle:生物钟与非酒精性脂肪性肝病
- Author:
Yanjun LIN
1
;
Su LIN
;
Yilong WU
;
Yueyong ZHU
Author Information
1. 福建医科大学附属第一医院肝病中心，福州 350005
- Keywords:
Circadian clock;
Circadian rhythm;
Non-alcoholic fatty liver disease;
Intestinal flora
- From:
Chinese Journal of Hepatology
2020;28(3):284-288
- CountryChina
- Language:Chinese
-
Abstract:
The circadian clock is a generator of self-sustaining physiological and behavioral rhythms, which can be guided by external environmental factors, so as to synchronize biological behaviors with external environmental changes. The modern lifestyles make the human body incapable of synchronization to the external time with the circadian rhythm, and thus form a social jet lag. Non-alcoholic fatty liver disease (NAFLD) is a disorder closely related to metabolic abnormalities. The circadian clock is closely related to metabolic abnormalities and NAFLD and changes among them may be involved with feeding mode and ingredients, sleeping time, and intestinal flora. Molecules associated with the circadian clock are expected to become potential drugs for the treatment of NAFLD. This article mainly reviews the latest research progress of circadian clock and NAFLD.
