Emphasis on clinical study of heterogeneity of non-alcoholic fatty liver disease
10.3760/cma.j.cn501113-20200317-00119
- VernacularTitle:重视非酒精性脂肪性肝病异质性的临床研究
- Author:
Leijie HUANG
1
;
Yanhuang XU
;
Jiangao FAN
Author Information
1. 上海交通大学医学院附属新华医院消化内科 上海市小儿消化与营养重点实验室 200092
- Keywords:
Fatty liver, non-alcoholic;
Metabolic disorder;
Alcohol;
Liver cirrhosis;
Natural history
- From:
Chinese Journal of Hepatology
2020;28(3):193-197
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease is the leading cause of chronic liver disease worldwide. Non-alcoholic fatty liver disease has a wide spectrum of diseases including simple fatty liver, steatohepatitis, liver fibrosis, and cirrhosis. The clinical manifestations and disease outcomes of patients with non-alcoholic fatty liver disease vary widely, and are related to the heterogeneity of risk factors, such as heredity, epigenetics, race, gender, age, diet, exercise, alcohol drinking, intestinal microecology, coexisting diseases, and hormone and metabolic status. Emphasizing the study of pathogenesis and clinical heterogeneity of patients with non-alcoholic fatty liver disease will help to layer the management of disease and improve the effectiveness of clinical trials.
