Diagnosis and therapeutic strategies for non-obese type of non-alcoholic fatty liver diseases
10.3760/cma.j.cn501113-20191226-00480
- VernacularTitle:非肥胖型非酒精性脂肪性肝病的诊治对策
- Author:
Huiting CHEN
1
;
Yongjian ZHOU
Author Information
1. 广州市第一人民医院，广州消化疾病中心，华南理工大学附属第二医院消化内科，广州 510180
- Keywords:
Fatty liver, non-alcoholic;
Non-obese;
Diagnosis;
Therapy
- From:
Chinese Journal of Hepatology
2020;28(3):203-207
- CountryChina
- Language:Chinese
-
Abstract:
Non-alcoholic fatty liver disease and obesity have interconnected genes, but it can also occur in non-obese population with body mass index < 25 kg/m 2. Non-obese type of non-alcoholic fatty liver disease mostly occurs in Asia. There is no significant difference between obese and non-obese type of non-alcoholic fatty liver in histological examination of liver biopsies. Visceral obesity, high fructose and cholesterol intake, and genetic factors such as APOC3 gene mutation are closely related to non-obese type of non-alcoholic fatty liver. Generally speaking, non-alcoholic steatohepatitis has an increased mortality rate, mainly due to cardiovascular causes, and has no link with other metabolic factors. Although data on the impact of mortality from non-obese type of non-alcoholic fatty liver disease are incomplete and limited, however diagnosis, management, and treatment may be important. Lifestyle changes to reduce visceral obesity, including dietary changes and physical activity, remain the main treatment options for patients with non-obese type of non-alcoholic fatty liver disease.
