Comorbidities and concomitant medication use in adult patients with chronic hepatitis C: a descriptive epidemiological analysis
10.3760/cma.j.issn.1007-3418.2018.03.011
- VernacularTitle:成人慢性丙型肝炎合并疾病及用药现状分析
- Author:
Qin WANG
1
;
Huiying RAO
;
Ning YU
;
Shuangqing GAO
;
Lai WEI
Author Information
1. 100044,北京大学人民医院北京大学肝病研究所丙型肝炎和肝病免疫治疗北京市重点实验室
- Keywords:
Hepatitis C,chronic;
Comorbidity;
Concomitant medications;
Drug-drug interactions
- From:
Chinese Journal of Hepatology
2018;26(3):225-232
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the comorbidity and concomitant medications use in adult patients with chronic hepatitis C.Methods A descriptive epidemiological methods was carried out in adult patients with chronic hepatitis C and data from 2013 to 2015 were accessed through the China Medical Insurance database.Results Among a chronic HCV cohort of 2 958 cases,the top five comorbidities were diabetes,hypertension,ischemic heart disease,gastroduodenitis,and co-infection with HBV and HCV.The three most common concomitant medications prescribed for mentioned comorbidities were acarbose,metformin and repaglinide (Diabetes),nifedipine,amlodipine and metoprolol (Hypertension),aspirin,nifedipine and amlodipine (Ischemic heart disease),omeprazole,pantoprazole and levolfoxacin (Gastroduodenitis),ribavirin,pegylated interferon alpha-2a and alpha-2b (Co-infected with hepatitis B and C virus).Conclusion The five most frequent comorbidities in adult patients with chronic hepatitis C are diabetes,hypertension,isehemic heart disease,gastroduodenitis,and co-infection with HBV and HCV.A concomitant medication use in those patients with comorbidities causes potential drug-drug interactions.
