Construction of risk prediction model for the extravasation of iodinated contrast agent injected by intravenous high pressure in tumor patients
10.3760/cma.j.cn211501-20240118-00175
- VernacularTitle:肿瘤患者静脉高压注射碘对比剂外渗风险预测模型的构建
- Author:
Jing LYU
1
;
Jiani ZHAO
;
Yueying ZHANG
Author Information
1. 山西医科大学护理学院，太原 030001
- Keywords:
Neoplasms;
Nomograms;
Iodinated contrast agent;
Contrast-enhanced CT;
Extravasation;
Risk prediction model
- From:
Chinese Journal of Practical Nursing
2024;40(20):1528-1534
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the risk factors of iodinated contrast agent extravasation in tumor patients with intravenous high pressure injection, and to develop a nomogram model of contrast agent extravasation, so as to provide reference for the detection of extravasation risk factors before examination.Methods:A retrospective case-control study was used in this study. Two hundred and two tumor patients with iodinatedcontrast agent extravasation who underwent enhanced CT examination in the Second Hospital of Shanxi Medical University, Shanxi People′s Hospital and Shanxi tumor Hospital from September 2021 to September 2023 were selected by random sampling method as the case group, and 202 tumor patients without iodinated contrast agent extravasation who underwent enhanced CT examination in the above 3 hospitals during the same period were randomly selected as the control group. Multivariate Logistic regression was used to analyze the independent risk factors of iodinated contrast agent extravasation and a nomogram prediction model was established by R4.3.1 statistical software. The receiver operating characteristic (ROC) curve, calibration curve and Hosmer-Lemeshow goodness of fit test were used to evaluate the predictive efficiency of the model.Results:A total of 404 tumor patients were included in this study. There were 97 males and 105 females in the case group, aged 30-88 (62.97 ± 0.91) years old; and 123 males and 79 females in the control group, aged 31-85 (61.38 ± 0.73) years old. Multivariate Logistic regression analysis showed that age, sex, injection rate, contrast agent concentration, contrast osmotic concentration, long-term chemotherapy and nurses′ working years were independent risk factors for iodinated contrast agent extravasation ( OR values were 0.306-6.365, all P<0.05). The area under the ROC curve predicted by the nomogram model was 0.814 (95% CI 0.714-0.875), the specificity was 78.1%, the sensitivity was 70.2%, the slope of calibration curve was close to 1, and the Hosmer-Lemeshow goodness of fit test χ2 = 11.47, P>0.05. Conclusions:The nomogram model established in this study can accurately predict the risk of iodinated contrast agent extravasation in tumor patients, and provide a reference for the detection of high-risk factors of extravasation before examination.
