NACHT-LRR-PYD-containing proteins 3 inflammasome and nonalcoholic fatty liver disease
10.3760/cma.j.issn.1007-3418.2016.12.019
- VernacularTitle:NLRP3炎症小体与非酒精性脂肪性肝病
- Author:
Xiaojuan GAO
1
;
Su LIN
;
Yueyong ZHU
Author Information
1. 福建医科大学附属第一医院肝病中心
- Keywords:
Fatty liver;
Non-alcoholic steatohepatitis;
Fatty acid;
NLRP3 inflammasome
- From:
Chinese Journal of Hepatology
2016;24(12):956-960
- CountryChina
- Language:Chinese
-
Abstract:
NACHT-LRR-PYD-containing proteins 3 (NLRP3) inflammasome regulates the maturation and secretion of proinflammatory cytokines including interleukin-1β and interleukin-18,as well as immune and inflammatory response,through the activation of cysteine aspartate specific protease-1.Inflammatory response caused by the activation of NLRP3 inflammasome may participate in the development and progression of nonalcoholic fatty fiver disease (NAFLD).Therefore,exploration of the role ofNLRP3 inflammasome in NAFLD is important for the understanding of the pathogenesis of NAFLD and discovery of new therapeutic targets.
