Short-and long-term efficacy of CT-guided percutaneous microwave ablation for the treatment of hepatocellular carcinoma
10.3969/j.issn.1002-1671.2024.12.029
- VernacularTitle:CT引导下经皮微波消融术治疗肝细胞癌的近远期疗效观察
- Author:
Gang LIU
1
;
Chenghuan LIU
;
Xiaoting XIE
;
Hui HE
;
Liang YAO
;
Baokui ZHAO
;
Hengwei WANG
;
Zhao FENG
Author Information
1. 青海红十字医院放射影像介入科,青海 西宁 810000
- Keywords:
hepatocellular carcinoma;
CT-guided;
percutaneous microwave ablation;
tumor markers;
liver function
- From:
Journal of Practical Radiology
2024;40(12):2058-2061
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of CT-guided percutaneous microwave ablation for the treatment of primary hepatocellular carcinoma.Methods A total of 132 patients with primary hepatocellular carcinoma were divided into control group and study group(66 cases in each group)according to different treatment plans.The control group received transcatheter arterial chemoembolization(TACE)treatment,while the study group received TACE combined with percutaneous microwave ablation under CT guidance.The changes in serum tumor markers and liver function indicators were observed before and after treatment in the two groups,and the efficacy(short-and long-term)and safety of the two groups were compared.Results The levels of serum carcinoembryonic antigen(CEA),alpha-fetoprotein(AFP),carbohydrate antigen 125(CA125),and carbohydrate antigen 19-9(CA19-9)in both groups decreased significantly after treatment compared to those before treatment,and intergroup comparison showed that the levels of CEA,AFP,CA125,and CA1 9-9 in the study group were significantly lower those after treatment(P＜0.05).Compared with those before treatment,the levels of alanine transaminase(ALT)and aspartate transaminase(AST)were decreased,and the level of albumin(ALB)was increased of both groups after treatment.The intergroup comparison showed that the study groups ALT and AST levels were lower and ALB level was higher(P＜0.05).The total effective rate of the study group was clearly higher than that of the control group(75.76％vs 46.97％,P＜0.05).The 1-year survival rates of the two groups were similar(90.91％vs 81.82％,P＞0.05),however,the 2-year survival rate of the study group was clearly higher than that of the control group(84.85％vs 63.64％,P＜0.05).Conclusion CT-guided percutaneous microwave ablation for the adjuvant TACE treatment of primary hepatocellular carcinoma can effectively reduce tumor burden and lower tumor marker levels,its short-and long-term efficacy is significant,with a low incidence of adverse reactions and good safety.
