Serum CXCL-10 level in chronic hepatitis C patients with cryoglobulinemia and its influence on antiviral therapy
10.3760/cma.j.issn.1007-3418.2016.10.006
- VernacularTitle:慢性丙型病毒性肝炎冷球蛋白血症患者血清CXC趋化因子10水平及其对抗病毒治疗的影响
- Author:
Xiaohong FAN
1
;
Zhihua DENG
;
Xiaoyuan XU
Author Information
1. 山西医科大学第二医院消化肝病科
- Keywords:
Cryoglobulinemia;
Hepatitis C;
Pegylated interferon alfa-2a;
CXC chemokine ligand-10;
Virological response
- From:
Chinese Journal of Hepatology
2016;24(10):744-748
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum CXCL-10 level in chronic hepatitis C (CHC) patients with cryoglobulinemia and its influence on the effect of antiviral therapy.Methods A total of 50 CHC patients were enrolled in the study.Cryoprecipitation was used to determine the nature of cryoglobulins in serum before treatment,and ELISA was used to measure the serum CXCL-10 level.The hepatitis C virus (HCV) genotype was detected,and serum HCV RNA level was measured at baseline,4,12,and 24 weeks of treatment,the end of treatment,and 24 weeks after treatment..Results Compared with the cryoglobulin-negative patients,the cryoglobulin-positive patients had significantly higher baseline levels of HCV RNA [(6.28±0.79) logl0 copies/ ml vs (5.48±1.20) log10 copies/ml,P =0.009] and CXCL-10 (541.67±224.07 pg/ml vs 394.39±179.71 pg/ ml,P =0.015).After the treatment with pegylated interferon-α-2a and ribavirin,the cryoglobulin-positive patients had a significantly lower proportion of individuals who achieved rapid virological response compared with the cryoglobulin-negative patients (33.3％ vs 82.6％,P ＜ 0.001).The cryoglobulin-positive patients had a significantly lower rate of sustained virologic response than the cryoglobulin-negative patients (33.3％ vs 78.3％,P =0.001).Conclusion The patients with cryoglobulinemia have higher serum levels of HCV RNA and CXCL-10 and poor outcomes compared with those without cryoglobulinemia.
