Analysis of imaging and clinical features of phosphaturic mesenchymal tumor
10.3969/j.issn.1002-1671.2024.12.022
- VernacularTitle:磷酸盐尿性间叶肿瘤的影像学与临床特征分析
- Author:
Junping LAN
1
;
Jiageng XIE
;
Yushi PENG
;
Yimin CHEN
;
Zhe XIAO
;
Hanzhe WANG
;
Xiangwu ZHENG
Author Information
1. 温州医科大学附属第一医院放射科,浙江 温州 325000
- Keywords:
phosphaturic mesenchymal tumor;
osteomalacia;
hypophosphatemia;
imaging;
octreotide
- From:
Journal of Practical Radiology
2024;40(12):2029-2032
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical and imaging features of phosphaturic mesenchymal tumor(PMT).Methods The clinical presentations,laboratory examinations,and imaging manifestations of seven patients with PMT diagnosed by surgery and pathology were analyzed retrospectively.Results Among the 7 patients,four patients had clinical presentations of long-term fatigue and bone pain.All patients showed preoperative blood phosphorus reduction in varying degrees.X-ray examination showed systemic osteomalacia and osteoporosis,accompanied by multiple pathological fractures.On CT,the primary tumor appeared as a soft tissue density mass or a ground glass high-density nodule with irregular calcification and local bone destruction.MRI showed long T1,long T2 signal intensity,and irregular low signal foci were scattered in the T2WI fat-suppressed sequence.The enhanced scans showed moderate to significant inhomogeneous enhancement.One patient who underwent 18F-FDG PET/CT and two patients who underwent 18F-ALF-NOTA-Octreotide(18F-OC)PET/CT examinations showed varying degrees of radioactive concentration in the lesions.Conclusion The clinical presentations and laboratory examinations of patients with PMT have certain characteristics.Systemic osteomalacia with pseudofracture line,calcification matrix within the tumor,and significant inhomogeneous enhancement of the lesion are the key imaging features for diagnosing PMT.18F-OC PET/CT examination plays a crucial role in the systemic localization diagnosis of tumors.
