Mendelian randomization study of abdominal subcutaneous adipose tissue volume and cardiovascular disease risk
10.3969/j.issn.1002-1671.2024.12.009
- VernacularTitle:腹部皮下脂肪组织体积与心血管疾病风险的孟德尔随机化研究
- Author:
Yanming ZHANG
1
;
Rui YAO
;
Lei ZHONG
Author Information
1. 湖州市中心医院放射科,浙江 湖州 313000
- Keywords:
abdominal subcutaneous adipose tissue;
cardiovascular disease;
Mendelian randomization
- From:
Journal of Practical Radiology
2024;40(12):1974-1978
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the causal relationship between abdominal subcutaneous adipose tissue volume(ASAT)measured by MRI and cardiovascular disease risk with Mendelian randomization(MR).Methods Genome-wide association study(GWAS)data for ASAT measured by MRI were provided by the IEU OpenGWAS project,while GW AS data for cardiovascular disease came from the Finngen database.The primary analysis method employed was the inverse variance weighted(I VW)method.Additional MR analysis methods,included MR-Egger regression,weighted median(WME),simple mode method,and weighted model method.Heterogeneity,horizontal pleiotropy and leave-one-out sensitivity analysis were conducted to verify the robustness of the results and funnel plots were used to verify the evaluation.Scatter plots were used to visualize the causal relationship between ASAT and cardiovascular disease.Results There was a causal relationship between ASAT and the risk of ischemic heart disease(IHD)[odds ratio(OR)1.126,95％confidence interval(CI)1.042-1.217,P=0.003)],heart failure(HF)(OR 1.145,95％CI 1.024-1.281,P=0.017),and hypertension(OR 1.096,95％CI 1.014-1.184,P=0.021),but there was no significant causal relationship with cardiac arrest(CA)(P＞0.05).Heterogeneity was observed in the analysis of ASAT with IHD(Cochran's Q=53.467,P=0.018),HF(Cochran's Q=54.761,P=0.013),and hypertension(Cochran's Q=55.321,P=0.002).Further horizontal pleiotropy MR-Egger intercept tests and funnel plots indicated no horizontal pleiotropy in MR analysis(P＞0.05).Leave-one-out sensitivity analysis results demonstrated the robustness of the study findings.Conclusion There is a causal relationship between ASAT measured by MRI and the risk of IHD,HF,and hypertension.This highlights the need for clinical practitioners to pay attention to the cardiovascular disease risk in obese patients,especially those with abdominal obesity.
