Degree centrality study of resting-state functional MRI in elderly patients with chronic insomnia disorder
10.3969/j.issn.1002-1671.2024.12.005
- VernacularTitle:老年慢性失眠障碍患者静息态功能MRI的度中心度研究
- Author:
Qianqian GAO
1
;
Haixia MAO
;
Siyuan ZENG
;
Lin MA
;
Xiangming FANG
Author Information
1. 南京医科大学无锡医学中心 无锡市人民医院 南京医科大学附属无锡人民医院医学影像科,江苏 无锡 214023
- Keywords:
chronic insomnia;
resting-state functional magnetic resonance imaging;
degree centrality;
insula;
rolandic operculum
- From:
Journal of Practical Radiology
2024;40(12):1953-1957
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of resting-state degree centrality(DC)in elderly patients with chronic insomnia disorder(CID).Methods Resting-state functional magnetic resonance imaging(rs-fMRI)data were collected from 26 untreated elderly patients with CID(CID group)and 45 healthy controls(HC)(HC group).Two-sample t-test was conducted to compare the intergroup differences in whole-brain DC values,and the correlation between DC values in different brain regions and clinical indicators were analyzed,and logistic regression analysis was performed to verify the diagnostic efficacy of changes in DC values for elderly CID.Results Compared with the HC group,the DC values of the right insula,left rolandic operculum,and opercular part of right inferior frontal gyrus in the elderly CID group decreased[P＜0.05,false discovery rate(FDR)corrected],while the DC values of the right middle frontal gyrus increased(P＜0.05,FDR corrected).And the DC values of the opercular part of right inferior frontal gyrus in the elderly CID group were positively correlated with sleep efficiency(r=0.504,P=0.009)and self-rating depression scale(SDS)(r=0.401,P=0.042),respectively.The sensitivity of DC value in the opercular part of right inferior frontal gyrus for diagnosing elderly CID was 0.822,the specificity was 0.615,and the accuracy was 0.701.Conclusion Elderly CID patients have abnormal DC values in the right insula,left rolandic operculum,opercular part of right inferior frontal gyrus and right middle frontal gyrus,which may provide imaging evidence for exploring the pathogenesis of CID and clinical diagnosis and treatment.
