Changes in serum β2-microglobulin, retinol-binding protein, and cystatin C and their value in identifying early renal dysfunction in patients with chronic hepatitis B undergoing tenofovir or entecavir monotherapy: a comparative analysis
10.3760/cma.j.issn.1007-3418.2016.09.002
- VernacularTitle:血清中β2微球蛋白、视黄醇结合蛋白、胱抑素C在替诺福韦或恩替卡韦单药治疗慢性乙型肝炎早期肾功能变化中的意义
- Author:
Jia HE
1
;
Huibin NING
;
Yanli ZENG
;
Wei LI
;
Kuan LI
;
Jia SHANG
Author Information
1. 河南省人民医院感染科
- Keywords:
Hepatitis B,chronic;
Retinol-binding proteins;
Cystatin C
- From:
Chinese Journal of Hepatology
2016;24(9):643-646
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the dynamic changes in serum β2-microglobulin,retinolbinding protein,and cystatin C in chronic hepatitis B (CHB) patients treated with tenofovir or entecavir alone as the anti-HBV therapy,as well as their value in identifying early renal dysfunction.Methods A total of 61 previously untreated CHB patients who were diagnosed and treated in the Department of Infectious Diseases in Henan Provincial People's Hospital from June 2013 to August 2015 were enrolled and divided into tenofovir group and entecavir group.The serum levels of β2-microglobulin,retinol-binding protein,cystatin C,and creatinine and estimated glomerular filtration rate (eGFR) were compared between the two groups at baseline and 4,8,39,52,78,and 104 weeks after antiviral therapy.The independent samples t-test was used for comparison of continuous data,and the chi-square test was used for comparison of categorical data.P ＜ 0.05 was considered statistically significant.Results A total of 61 CHB patients were enrolled,with 31 in the tenofovir group and 30 in the entecavir group.The two groups had comparable serum levels of β2-microglobulin,retinol-binding protein,and cystatin C at baseline,but there were significant differences in β2-microglobulin and retinol-binding protein over time (both P ＜ 0.05).There was a significant difference in cystatin C at 78 weeks (t =-2.062,P =0.044),but there was no significant difference at 104 weeks (t =-1.544,P=0.128).There were no significant differences in serum creatinine or eGFR at any time point between the two groups (P ＞ 0.05).At 104 weeks,there were no significant differences in HBV-DNA clearance rate or the level of virologic breakthrough between the two groups (P ＞ 0.05).Conclusion Serum β2-microglobulin,retinol binding protein,and cystatin C are more sensitive than eGFR in the monitoring of early renal dysfunction during the anti-HBV therapy with tenofovir or entecavir alone.
