Effect of altered oxidative stress system on liver function after partial splenic embolization
10.3969/j.issn.1002-1671.2024.11.028
- VernacularTitle:部分脾动脉栓塞术后氧化应激系统改变对肝功能的影响
- Author:
Haoqin ZHAO
1
;
Jihong HU
;
Wenqiu PAN
;
Wei ZHAO
;
Yuanjin MA
;
Yubo ZHANG
;
Zhifu TIAN
Author Information
1. 昆明医科大学第一附属医院介入科,云南 昆明 650032
- Keywords:
liver cirrhosis;
hypersplenism;
partial splenic embolization;
oxidative stress system;
liver function
- From:
Journal of Practical Radiology
2024;40(11):1880-1883
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of altered oxidative stress system on liver function after partial splenic embolization(PSE).Methods Twenty-nine patients with liver cirrhosis and hypersplenism who received PSE were selected.Peripheral venous blood was drawn from the patients before and at 1 week,1 month,and 3 months after PSE,and the indexes of oxidative stress system factors including malondialdehyde(MDA),superoxide dismutase(SOD),advanced oxidiation protein products(AOPPs),and gluta-thione peroxidase(GSH-Px)were detected,as well as liver function indexes.Results There were positive correlation between SOD activity and total bilirubin(TBil)and model for end-stage liver disease(MELD)scores at 1 week postoperatively(TBil:r=0.725,P＜0.05;MELD:r=0.764,P＜0.05).There was positive correlation between GSH-Px activity and alanine aminotransferase(ALT)at 1 month postoperatively(r=0.777,P＜0.05),however,the AOPPs was negatively correlated with ALT and aspartate aminotransferase(AST)at 3 months postoperatively(ALT:r--0.900,P＜0.05;AST:r=-0.957,P＜0.05).Conclusion PSE can improve the body oxidative stress system and enhance the body's antioxidant response,and then improve the liver function.
