Clinical features of liver cirrhosis complicated by portal vein thrombosis and related risk factors
10.3760/cma.j.issn.1007-3418.2016.07.006
- VernacularTitle:肝硬化合并门静脉血栓形成的临床特点及其相关危险因素分析
- Author:
Guoshuai LIN
1
;
Qin XU
;
Shuyi ZHAO
;
Yuexin ZHANG
Author Information
1. 新疆医科大学第一附属医院感染性疾病中心
- Keywords:
Liver cirrhosis;
Portal vein;
Thrombosis;
Clinical characteristics;
Risk factors
- From:
Chinese Journal of Hepatology
2016;24(7):513-517
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features of patients with liver cirrhosis complicated by portal vein thrombosis (PVT) and related risk factors.Methods A total of 65 patients with liver cirrhosis complicated by PVT who were diagnosed and treated from June 2013 to June 2015 were enrolled as PVT group,and 70 cirrhotic patients without PVT were enrolled as controls (non-PVT group).The data collected included general information,results of laboratory examination,imaging findings,clinical manifestations,and complications.The clinical features were compared between the two groups,and related risk factors were screened out.Results There were no significant differences between the PVT group and non-PVT group in age,sex,nation,etiology,white blood cell count,platelet count,international normalized ratio,activated partial thromboplastin time,fibrinogen,serum creatinine,total bilirubin,and the diameter of the splenic vein (allP ＞ 0.05),while between these two groups,there were significant differences in D-dimer (1.87±1.45 mg/ml vs 0.55±0.58mg/ml,P ＜ 0.05),fibrinogen degradation product (FDP) level (18.57±19.46 μg/ml vs 5.45±6.00 μg/ml,P ＜ 0.05),hemoglobin (99.32±26.73 g/L vs 112.64±25.03 g/L,P ＜ 0.05),albumin (28.51±5.19 g/L vs 33.07±7.94 g/L,P ＜0.05),the diameter of the portal vein (12.53±2.70 mm vs 11.17±1.79 mm,P ＜ 0.05),spleen thickness (5.12±0.95cm vs 4.56±0.83 cm,P ＜ 0.05),spleen length (15.35±3.21 cm vs 13.86±2.82 cm,P ＜ 0.05),and Child-Pugh score (7.66±2.06 vs 6.93±1.87,P ＜ 0.05).The two groups showed no significant differences in diarrhea,ileus,hepatorenal syndrome,and hepatic encephalopathy (P ＞ 0.05),but showed significant differences in abdominal pain (18 vs 7 cases,P ＜ 0.05),fever (17 vs 4 cases,P ＜ 0.05),esophageal variceal bleeding (22 vs 9 cases,P ＜0.05),and spontaneous peritonitis (24 vs 12 cases,P ＜ 0.05).D-dimer (OR =4.290,P ＜ 0.000) and mean platelet volume (OR =1.294,P =0.023) were independent risk factors for PVT in patients with liver cirrhosis.Conclusion Cirrhotic patients with a high degree of liver cirrhosis,high levels of D-dimer and FDP and a large diameter of the portal vein tend to have a high incidence rate of PVT.PVT can aggravate the clinical symptoms and significantly increase complications in patients with liver cirrhosis.An increased D-dimer level and a greater width of the main portal vein are independent risk factors for PVT in patients with liver cirrhosis.
