A cortical thickness study of insomnia disorder patients based on MRI
10.3969/j.issn.1002-1671.2024.11.003
- VernacularTitle:基于MRI的失眠障碍患者大脑皮层厚度研究
- Author:
Wei CHEN
1
,
2
;
Hui WANG
;
Ziyi LIU
;
Yu SHANG
;
Haining LI
;
Wenxuan HAN
;
Qiange ZHU
;
Ming ZHANG
Author Information
1. 西安交通大学,陕西 西安 710049
2. 安康市中医医院影像科,陕西 安康 725000
- Keywords:
insomnia disorder;
cortical thickness;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2024;40(11):1766-1769
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of cortical thickness in patients with insomnia disorder(ID).Methods High-resolution MRI data were collected from 32 ID patients(ID group)and 30 healthy controls(HC)(HC group).The cortical thickness of both groups were analyzed using statistical parametric mapping 12(SPM12)software,while considering age,gender,and educational level as covariates.The cortical thickness in brain regions showed statistically significant differences was extracted for Pearson's correla-tion analyses with sleep and mood-related scales.Results Compared with the HC group,the ID group exhibited significantly decreased cortical thickness in brain regions such as the left insula,fusiform gyrus,orbitofrontal lobe,superior temporal gyrus,middle temporal gyrus,lateral occipital lobe and right caudal anterior cingulate gyrus[P＜0.05,family-wise error(FWE)correction].Furthermore,reduced cortical thickness of the cingulate gyrus was negatively correlated with the Pittsburgh sleep quality index(PSQI)score(r=-0.437,P=0.012).Conclusion The cortical thickness of several brain regions associated with sleep and mood are significantly reduced in patients with ID,providing potential neuroimaging evidence for understanding the pathophysiological mechanism of ID.
