Association between chronicity of HBV infection and host immunity
10.3760/cma.j.issn.1007-3418.2016.06.018
- VernacularTitle:乙型肝炎病毒感染慢性化与宿主免疫
- Author:
Xiaobo SHANG
1
;
Qian ZHAO
;
Caiyan ZHAO
Author Information
1. 河北医科大学第三医院感染科
- Keywords:
Hepatitis B virus;
Immunity,natural;
Adaptive immunity;
Signal transduction
- From:
Chinese Journal of Hepatology
2016;24(6):474-477
- CountryChina
- Language:Chinese
-
Abstract:
The prognosis of hepatitis B virus (HBV) infection is determined by innate immunity,adaptive immunity,and a variety of regulatory factors in the host.Controversy still exists over the role of innate immunity in the progression of HBV infection.Adaptive immunity,especially the immune response mediated by CD8+ T cells,plays an important role in HBV clearance.However,in patients with chronic infection,such CD8+ T cells are often exhausted and associated with various regulatory factors including programmed cell death 1 and T-cell immunoglobulin mucin-3.This article elaborates on the association of chronicity of HBV infection with host immune system and various regulating factors.
