Research advances in the role of interleukin-21 in chronic hepatitis B virus infection
10.3760/cma.j.issn.1007-3418.2016.06.017
- VernacularTitle:白细胞介素21在慢性乙型肝炎病毒感染中作用的研究进展
- Author:
Rong DING
1
,
2
;
Shiwu MA
Author Information
1. 650032 成都军区昆明总医院感染科
2. 昆明医科大学成都军区 昆明总医院临床学院
- Keywords:
Interleukin-21;
Hepstitis B,chronic;
Liver cirrhosis;
Liver failure;
Carcinoma,hepatocellular;
Glomerulonephritis,membranous
- From:
Chinese Journal of Hepatology
2016;24(6):469-473
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin-21 (IL-21) is a cytokine mainly secreted by activated CD4+ T cells and natural killer T cells and has multiple effects.It is involved in innate and adaptive immune responses.Recent studies have shown that IL-21 can promote functional activation of various immune cells in the process of hepatitis B virus (HBV) infection,and the gene polymorphisms of IL-21 is associated with the susceptibility to HBV.In addition,the expression of IL-21 is closely associated with HV genotype,HBV clearance,HBeAg seroconversion,HBV-related liver cirrhosis,liver failure,liver cancer,and autoimmune disease.This article reviews the research advances in clinical trials with reference to the aspects above.
