Value of three-dimensional amide proton transfer imaging and multi-model diffusion weighted imaging in assessing the histological grade of cervical squamous cell carcinoma
10.3969/j.issn.1002-1671.2024.10.018
- VernacularTitle:三维酰胺质子转移成像与多模型扩散加权成像评估宫颈鳞状细胞癌组织学分级的价值
- Author:
Wenjing LI
1
;
Shujian LI
;
Yimeng KANG
;
Zanxia ZHANG
;
Yong ZHANG
;
Jingliang CHENG
;
Weijian WANG
Author Information
1. 郑州大学第一附属医院磁共振科,河南 郑州 450052
- Keywords:
cervical squamous cell carcinoma;
magnetic resonance imaging;
amide proton transfer imaging;
diffusion weighted imaging
- From:
Journal of Practical Radiology
2024;40(10):1658-1662
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of three-dimensional amide proton transfer(3D APT)imaging and multi-model diffusion weighted imaging(DWI)in evaluating the histological grade of cervical squamous cell carcinoma(CSCC).Methods A total of 54 patients with CSCC at different grades were prospectively included.All subjects underwent pelvic 3D APT and multi-b-value DWI sequences on a 3.0T MR scanner.Two radiologists blindly measured the amide proton transfer(APT)values of all continuous layers of the lesion,the apparent diffusion coefficient(ADC)of the mono-exponential-model of DWI,the ture-diffusion coefficient(D),pseudo-diffusion coefficient(D*),perfusion fraction(f)of intravoxel incoherent motion(IVIM)imaging,and the mean diffusivity(MD)and mean diffusion kurtosis(MK)values of diffusion kurtosis imaging(DKI).The receiver operating characteristic(ROC)curve was used to analyze the efficacy of each parameter in identifying different pathological grades of CSCC.Results The APT mean signal intensity(SImean),APT maximum signal intensity(SImax)and maximum mean diffusion kurtosis(MKmax)values of the high-grade group were statistically higher than those of the low-grade group,and the minimum apparent diffusion coefficient(ADCmin),minimum ture-diffusion coefficient(Dmin),and minimum mean diffusivity(MDmin)values were statistically lower than those of the low-grade group(P＜0.05).The area under the curve(AUC)increased after the combination of APT parameters and DWI parameters,which was obviously higher than that of a single parameter(P＜0.05).Conclusion Both APT and multi-model DWI are helpful to identify the degree of differentiation of CSCC,and the diagnostic value of combining the two is higher.
