Evaluation of Ki-67 expression in hepatocellular carcinoma by MR amide proton transfer imaging
10.3969/j.issn.1002-1671.2024.10.015
- VernacularTitle:MR酰胺质子转移成像评估肝细胞肝癌Ki-67表达研究
- Author:
Jingcheng HUANG
1
,
2
;
Wenjian WANG
;
Xin YANG
;
Jun SUN
;
Jianxiong FU
;
Jing YE
;
Xianfu LUO
Author Information
1. 苏北人民医院医学影像科,江苏 扬州 225001
2. 蚌埠医科大学第一附属医院放射科,安徽 蚌埠 233000
- Keywords:
hepatocellular carcinoma;
magnetic resonance imaging;
amide proton transfer imaging
- From:
Journal of Practical Radiology
2024;40(10):1645-1648
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between amide proton transfer-weighted(APTw)value derived from APTw imaging and Ki-67 expression in hepatocellular carcinoma.Methods Sixty patients with hepatic occupations underwent preoperative upper abdominal MRI scanning,including APTw and diffusion weighted imaging(DWI)sequences.Thirty-two patients with hepatocellular carcinoma proved by pathological results were enrolled in the prospective study.The APTw and apparent diffusion coefficient(ADC)values of the lesions were measured from the corresponding APTw and ADC images,respectively.Mann-Whitney U test or independent sample t test was used to analyze the differences in APTw and ADC values between the high and low Ki-67 expression groups.Pearson correlation analysis was used to evaluate the correlation between APTw value,ADC value and Ki-67 expression level of hepatocellular carcinoma.The receiver operating characteristic(ROC)curve was used to evaluate the diagnostic efficacy of amide proton transfer(APT)parameter in differentiating high and low Ki-67 expression groups.Results The APTw values of high Ki-67 expression group(n=24)was higher than that of low Ki-67 expression group(n=8)[(1.33±0.77)％vs(0.64±0.58)％,P=0.026].There was no significant difference in ADC values between the two groups(0.82×10-3 mm2/s vs 0.86×10-3 mm2/s,P=0.679).The APTw values were positively correlated with Ki-67 expression(r=0.377,P=0.035),and the area under the curve(AUC)of APTw value＞1.24％for the diagnosis of high Ki-67 expression was 0.794,with a sensitivity of 67％and a specificity of 88％.Conclusion The APTw value of hepatocellular carcinoma is positively correlated with Ki-67 expression,which has certain diagnostic value for predicting the expression status of Ki-67.
