The value of diagnosis and classification of patients with Parkinson's disease via synthetic MRI
10.3969/j.issn.1002-1671.2024.10.001
- VernacularTitle:基于合成MRI技术对帕金森病患者诊断及分型的价值
- Author:
Jieqiong LI
1
;
Chen SONG
;
Bo YANG
;
Enfu DU
Author Information
1. 湖北医药学院附属太和医院医学影像中心,湖北 十堰 442000
- Keywords:
Parkinson's disease;
motor subtype;
gray matter nuclei;
synthetic magnetic resonance imaging
- From:
Journal of Practical Radiology
2024;40(10):1577-1581
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the changes of relaxation values of different brain gray matter nuclei in patients with Parkinson's disease(PD)by synthetic magnetic resonance imaging(SyMRI),and to explore the correlation between relaxation values and clinical subtypes of PD,so as to provide some imaging basis for the diagnosis and classification of PD.Methods A total of 53 patients with PD and 34 healthy controls(HC)were scanned by SyMRI sequence.The patients with PD were divided into early group(33 cases),middle and late group(20 cases),postural instability/gait difficulty(PIGD)group and tremor dominant(TD)group.The region of interest(ROI)was drawn manually and the T1,T2 and proton density(PrD)values of different brain gray matter nuclei were measured,respectively.The differences between the groups were compared.Results There were statistical differences between the PD group and the HC group in multiple gray matter nuclei and multiple relaxation value parameters(P＜0.05).There were statistical differences in the relaxation values of gray matter nuclei such as head of the caudate nucleus,body of the caudate nucleus,putamen,globus pallidus,thalamus,red nucleus,and substantia nigra among the early PD group,the middle and late PD group,and the HC group,and red nucleus PrD value had the most testing effectiveness in the diagnosis of early PD[area under the curve(AUC)0.823,P＜0.001].There were statistical differences in the relaxation values of gray matter nuclei such as head of the caudate nucleus,putamen,and thalamus between the PIGD group and the TD group(P＜0.05).Conclusion It is found that there are statistical differences in different nuclear relaxation values between PD patients and healthy people,as well as between PD patients with different clinical types via SyMRI,suggesting that SyMRI has a certain clinical value in the diagnosis and classification of PD.
