Influence of leptin receptor gene K109R polymorphism on the risk of nonalcoholic fatty liver disease and its interaction with PNPLA3 I148M polymorphism
10.3760/cma.j.issn.1007-3418.2016.05.009
- VernacularTitle:瘦素受体基因K109R多态性对非酒精性脂肪性肝病发病的影响及其与脂肪滋养蛋白3基因I148M多态性的交互作用
- Author:
Baiquan AN
1
,
2
;
Man JIANG
;
Yuting CHENG
;
Chen YUAN
;
Linlin LU
;
Yongning XIN
;
Shiying XUAN
Author Information
1. 266021 南京医科大学青岛临床医学院消化内科
2. 青岛市市立医院消化内二科
- Keywords:
Polymorphism,single nucleotide;
Nonalcoholic fatty liver;
Leptin receptor gene;
Patatin-like phospholipase domain-containing protein 3
- From:
Chinese Journal of Hepatology
2016;24(5):358-362
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of leptin receptor (LEPR) gene K109R polymorphism on the risk of nonalcoholic fatty liver disease (NAFLD) and its interaction with PNPLA3 I148M polymorphism in the Han Chinese population in Qingdao,China.Methods Blood samples were collected from 296 NAFLD patients and 321 healthy controls,and the genotypes of these patients were determined by PCR and genotyping.Related statistical analyses were performed to compare genotypes,alleles,and clinical data between the two groups.Generalized multifactor dimensionality reduction (GMDR) was used to investigate the interaction between LEPR K109R and PNPLA3 I148M genes.Results The distribution of LEPR K109R genotypes and alleles showed no significant differences between the NAFLD group and the control group (P ＞ 0.05).PNPLA3 I148M gene polymorphisms were closely associated with the risk of NAFLD,and the risk of NAFLD in G mutant gene carriers was 2.07 times that in patients who did not carry this gene (OR =2.07,95％ CI 1.423-3.013,P ＜ 0.001).The joint action of LEPR K 109R and PNPLA3 I 148M significantly increased the risk of NAFL (OR =3.393,95％ CI 1.856-6.201,P ＜ 0.001).Conclusion In the Han Chinese population in Qingdao,LEPR K109R gene polymorphism is not associated with the risk of NAFLD,but its interaction with PNPLA3 I148M polymorphism can significantly increase the risk of NAFLD.
