Prediction and preventive strategies for recurrence after surgery for hepatocellular carcinoma
10.3760/cma.j.issn.1007-3418.2016.05.004
- VernacularTitle:肝细胞癌术后复发的预测与预防策略
- Author:
Huliang JIA
1
;
Lunxiu QIN
Author Information
1. 复旦大学附属华山医院普外科复旦大学肿瘤转移研究所
- Keywords:
Carcinoma,hepatocellular;
Recurrence;
Prediction;
Prevention
- From:
Chinese Journal of Hepatology
2016;24(5):330-334
- CountryChina
- Language:Chinese
-
Abstract:
Many advances have been achieved in the clinical and basic studies on metastasis and recurrence of hepatocellular carcinoma (HCC) over the past 20 years.The achievements mainly include the following aspects:(1) a group of molecules related to metastasis and recurrence including osteopontin have been identified,and multi-molecular predictive models for metastasis have been established and optimized;(2) it has been found that the imbalance of immune response in tumor microenvironment is important in promoting metastasis and can be used to predict metastasis and recurrence;(3) it has been found and confirmed that interferon can prevent postoperative recurrence,and patients with a lower miR-26a expression level can achieve greater benefits;(4) the breakthroughs in liquid biopsy and immunotherapy bring a promising future for the prediction,prevention,and treatment of HCC metastasis and recurrence.However,these predictive models still need to be validated by multi-center studies,and the effects of adjuvant transarterial chemoembolization and targeted therapy with sorafenib still need further evaluation.
