Relationship between sleep fragmentation and left ventricular structure of MR in the elderly population:the Multi-Ethnic Study of Atherosclerosis

Pengpeng ZHANG; Yuanqiang ZHU; Jiali LIU; Minwen ZHENG

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Relationship between sleep fragmentation and left ventricular structure of MR in the elderly population:the Multi-Ethnic Study of Atherosclerosis

VernacularTitle:老年人群中睡眠碎片化与MR左心室结构的关系:动脉粥样硬化多种族研究
Author: Pengpeng ZHANG ¹ ; Yuanqiang ZHU ; Jiali LIU ; Minwen ZHENG
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1. 西安医学院,陕西西安 710068
Keywords: sleep fragmentation; magnetic resonance imaging; left ventricle
From: Journal of Practical Radiology 2024;40(9):1439-1443
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between sleep fragmentation(SF)parameters and left ventricular structure in a community-based elderly population using data collected from the Multi-Ethnic Study of Atherosclerosis(MESA)cohort.Methods A total of 1 404 participants from the MESA cohort who underwent polysomnography(PSG)and cardiac magnetic resonance(CMR)were included.PSG was used to assess SF parameters,including wake after sleep onset(WASO),arousal index-total(ArI-total),arousal index-rapid eye movement(ArI-REM),and arousal index-non-rapid eye movement(ArI-NREM).Left ventricular end-diastolic mass(LVEDM)was measured via CMR.Linear regression was employed to analyze the relationship between SF parameters and left ventricular mass to height ratio(LVHi).Results Univariate linear regression analysis showed that WASO[β 0.134;95％confi-dence interval(CI)0.023-0.052;P＜0.001],ArI-total(β 0.184;95％CI 0.203-0.362;P＜0.001),ArI-REM(β 0.116;95％CI 0.100-0.260;P＜0.001)and ArI-NREM(β 0.175;9 5％CI 0.176-0.323;P＜0.001)were positively correlated with LVHi.After adjust-ment for confounding factors in multivariate linear regression analysis,WASO(β 0.045;95％CI 0.001-0.024;P=0.033)was positively correlated with LVHi.WASO(β 0.089;95％CI 0.006-0.034;P=0.006)was significantly associated with increased LVHi in the female group but not in the male group.Conclusion In an ethnically diverse cohort,WASO is significantly associated with increased LVHi after adjustment for potential confounders,especially in the female elderly population.