Which animal models of nonalcoholic steatohepatitis-hepatocellular carcinoma (NASH-HCC) have more practical value in experimental investigations?
10.3760/cma.j.issn.1007-3418.2016.03.015
- VernacularTitle:哪些非酒精性脂肪性肝炎-肝癌动物模型更具实用价值?
- Author:
Nana DUAN
1
;
Jian WU
Author Information
1. 复旦大学基础医学院病原生物学系医学分子病毒重点实验室
- Keywords:
Non-alcoholic fatty liver disease (NAFLD);
Nonalcoholic steatohepatitis-associated hepatocellular carcinoma (NASH-HCC);
Animal models
- From:
Chinese Journal of Hepatology
2016;24(3):230-233
- CountryChina
- Language:Chinese
-
Abstract:
In the past,we used to think that hepatocellular carcinoma (HCC) only occurred when nonalcoholic fatty liver disease (NAFLD) progressed to liver cirrhosis.However,recent clinical studies have shown that HCC may occur during the stage of nonalcoholic steatohepatitis (NASH).The prevalence of NAFLD and the increasing incidence of NASH-associated HCC require the elucidation of the pathogenesis of NASH-HCC and the assessment of the efficacy of novel therapies as early as possible,while these evaluations need reliable animal models.This article reviews the characteristics of NASH-HCC models with a practical value to uncover the mysteries of NASH-HCC.
